Structure–activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors

The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents which suffered from extensive protein binding has been previously reported. The structure–activity relationships around the carboxylic acid substituent are described herein. This acid was replaced by several alternative functional groups in attempts to retain bioactivity while reducing protein binding. Only groups with an acidic proton retained activity, and analogs containing those groups maintained the protein binding inherent to this class of antibacterial agents.

Graphical abstractTo improve potency and reduce protein binding in a novel series of antibacterial translation inhibitors, the SAR of carboxylic acid replacements and bioisosteres such as in compound 31 was explored.Figure optionsDownload full-size imageDownload as PowerPoint slide