| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373498 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The mechanism by which prostaglandin synthase converts arachidonic acid to prostaglandin G2, creating five new chiral centers in the process, is still incompletely understood. The first radical intermediate has been characterized by EPR spectroscopy but subsequent proposed intermediates have not succumbed to detection. We report the synthesis of 7-thiaarachidonic acid designed to stabilize one of the proposed radical intermediates, which may allow its detection.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chris M. McGinley, Cyril Jacquot, Wilfred A. van der Donk,