| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373501 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Synthesis and characterization of an inert perchlorotriphenylmethyl triester radical, PTM-TE, are reported. PTM-TE was prepared by a facile 3-step synthesis using Friedel-Crafts reaction of tetrachlorobenzene with chloroform followed by ethoxycarbonylation and subsequent oxidation. PTM-TE is paramagnetic and exhibits a single sharp EPR spectrum. In solution, the EPR linewidth of PTM-TE is highly sensitive to the dissolved oxygen content, thus enabling accurate measurement of oxygen concentration (oximetry). In addition, the radical also shows high reactivity towards superoxide. The ester radical has the potential for use as a high-sensitive probe for determination of oxygen concentration and superoxide in biological systems.
Graphical abstractPerchlorotriphenylmethyl (trityl) triester radical: a potential sensor for superoxide and oxygen in biological systemsFigure optionsDownload full-size imageDownload as PowerPoint slide
