Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373502 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D4-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.
Graphical abstract8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D4-receptor ligand was synthesized using oxidative iododestannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alummoottil V. Joshua, Sanjay K. Sharma, Alicia Strelkov, John R. Scott, Mathew T. Martin-Iverson, Douglas N. Abrams, Peter H. Silverstone, Alexander J.B. McEwan,