| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373517 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of Leishmania donovani. Compound 8c has been identified as the most active analog of the series with IC50 value of 5.17 μM and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine.
Graphical abstractA series of indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity against Leishmania donovani.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shikha S. Chauhan, Leena Gupta, Monika Mittal, Preeti Vishwakarma, Suman Gupta, Prem M.S. Chauhan,