Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373519 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Series of benzothiazoles were synthesized and evaluated their inhibitory activities for NO production in lipopolysaccharide-activated macrophages. The most potent compound was the indole-containing benzothiazole 3c with 4.18 μM of IC50. The mechanistic study suggested that benzothiazoles inhibited NO production by the suppression of iNOS protein and mRNA expression. They also suppressed the expression of COX-2 through the NF-κB inactivation.
Graphical abstractSynthesis of series of benzothiazole derivatives and their inhibitory activities on the NO production in lipopolysaccharide-activated macrophages are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guo Hua Jin, Hua Li, Semi An, Jae-Ha Ryu, Raok Jeon,