| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373522 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
In this Letter we describe the design, synthesis, screening, and optimization of a new family of ADAMTS-5 inhibitors. These inhibitors display an original 1,2,4-triazole-3-thiol scaffold as a putative zinc binding-group. In vitro results are rationalized by in silico docking of the compounds in ADAMTS-5’s crystal structure.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lucie Maingot, Florence Leroux, Valérie Landry, Julie Dumont, Hideaki Nagase, Bruno Villoutreix, Olivier Sperandio, Rebecca Deprez-Poulain, Benoit Deprez,