| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373525 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Previous research on histamine H3 antagonists has led to the development of a pharmacophore model consisting of a central phenyl core flanked by two alkylamine groups. Recent investigation of the replacement of the central phenyl core with heteroaromatic fragments resulted in the preparation of novel 3,5-, 3,6- and 3,7-substituted indole and 3,5-substituted benzothiophene analogs that demonstrate good to excellent hH3 affinities. Select analogs were profiled in a rat pharmacokinetic model.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Alejandro Santillan Jr., Kelly J. McClure, Brett D. Allison, Brian Lord, Jamin D. Boggs, Kirsten L. Morton, Anita M. Everson, Diane Nepomuceno, Michael A. Letavic, Alice Lee-Dutra, Timothy W. Lovenberg, Nicholas I. Carruthers, Cheryl A. Grice,