| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373538 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A novel series of piperidine-based renin inhibitors with improved efficacy in a double transgenic rat model is reported. Piperidines such as 41 (IC50 in plasma = 5.6 nM) showed high efficacy on blood pressure reduction (â36 mmHg) at low dose (3 mg/kg).
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Authors
Olivier Corminboeuf, Olivier Bezençon, Corinna Grisostomi, ĽuboÅ¡ RemeÅ, Sylvia Richard-Bildstein, Daniel Bur, Lars Prade, Patrick Hess, Panja Strickner, Walter Fischli, Beat Steiner, Alexander Treiber,