| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373539 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor with a suitable profile for development is described.
Graphical abstractThe optimization of the 4-position of 3,4-disubstituted piperidine-based renin inhibitors is reported herein. This work culminated in the discovery of 11, a renin inhibitor with a suitable profile for development.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Olivier Corminboeuf, Olivier Bezençon, Ľuboš Remeň, Corinna Grisostomi, Sylvia Richard-Bildstein, Daniel Bur, Lars Prade, Panja Strickner, Patrick Hess, Walter Fischli, Beat Steiner, Alexander Treiber,