| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373563 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).
Graphical abstractNovel analogues of the microtubule-stabilising agent dictyostatin were designed, synthesised and evaluated in vitro for growth inhibition against a range of human cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ian Paterson, Nicola M. Gardner, Karine G. Poullennec, Amy E. Wright,