| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373571 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Two sesterterpene sulfates (1–2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds 1 and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C2 carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease.
Graphical abstractThe isolation and bioactivity of three sesterterpene sulfates are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hyi-Seung Lee, Tae-Hoon Lee, Seung Hwan Yang, Hee Jae Shin, Jongheon Shin, Ki-Bong Oh,