| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373581 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (Ki = 3 nM) and good in vitro metabolic stability.
Graphical abstractA series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (Ki = 3 nM) and good in vitro metabolic stability.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mingzhu Zhang, Junko Tamiya, Linh Nguyen, Martin W. Rowbottom, Brian Dyck, Troy D. Vickers, Jonathan Grey, David A. Schwarz, Christopher E. Heise, Jason Haelewyn, Monica S. Mistry, Val S. Goodfellow,