Article ID Journal Published Year Pages File Type
1373592 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

A novel lipid analog based on amino acids for liposome modification was developed. It consisted of three different kinds of amino acid derivatives and two fatty acids, and can react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) was synthesized and successfully incorporated into liposome. The liposome containing the lipopeptide bearing HIV-TAT exhibited efficient cellular uptake.

Graphical abstractA convenient synthetic route for novel lipopeptide modified with TAT has been established, and functionalized liposome was successfully prepared and efficiently incorporated into living cells.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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