Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373599 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of β-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one (10f), showed potent in vitro activity, good selectivity and in vivo efficacy in mouse models. Also, the binding mode of compound 10f was determined by X-ray crystallography.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jin Hee Ahn, Mi Sik Shin, Mi Ae Jun, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Nam Sook Kang, Sun Young Kim, Sang-Kwon Sohn, Sung Gyu Kim, Mi Sun Jin, Jie Oh Lee, Hyae Gyeong Cheon, Sung Soo Kim,