| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373726 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Antimicrobial activity of synthesized 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives indicated that 3-(4-chlorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a,4,5,6,7-hexahydro-2H-indazole (6) and 3-(4-fluorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a,4,5,6,7-hexahydro-2H-indazole (20) were the most active compounds. Further, the results of QSAR studies indicated the importance of topological parameters 2χ and 2χv in defining the antimicrobial activity of hexahydroindazoles.
Graphical abstractQSAR study of synthesized hexahydroindazole derivatives indicated the importance of topological parameters 2χ and 2χv in contribution to antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maninder Minu, Ananda Thangadurai, Sharad Ramesh Wakode, Shyam Sundar Agrawal, Balasubramanian Narasimhan,