| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373732 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.
Graphical abstractThe development of optimum cationic lipids for cationic liposome delivery systems.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bieong-Kil Kim, Kyung-Oh Doh, Joo Hyeung Nam, Hyungu Kang, Jong-Gu Park, Ik-Jae Moon, Young-Bae Seu,