Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373736 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles has been synthesised regioselectively in good yields from the reaction of 5-aryldihydro-3(2H)-thiophenones and arylhydrazine hydrochloride. This reaction is found to be assisted by microwaves. The thieno[3,2-b]indoles were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug resistant M. tuberculosis (MDR-TB). Among 22 compounds screened, [2-(2,4-dichlorophenyl)-7-fluoro-3,4-dihydro-2H-thieno[3,2-b]indole] (6t) was found to the most active compound with MIC of 0.4 μg/mL against MTB and MDR-TB.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Subramanian Vedhanarayanan Karthikeyan, Subbu Perumal, Krithika Arun Shetty, Perumal Yogeeswari, Dharmarajan Sriram,