| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373749 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC50 values less then 0.1 μM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.
Graphical abstractStructure–activity relationship of a new class of Kv1.5 inhibitors based on the tetraline scaffold was investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Michael F. Gross, Neil A. Castle, Anruo Zou, Alan D. Wickenden, Weifeng Yu, Kerry L. Spear,