| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373750 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of pyridopyrimidine derivatives were synthesized and evaluated for their ability to inhibit cyclic nucleotide synthesis in the presence of stable toxin a of Escherichia coli. The structure activity relationships around the basic core structure were examined and examples with better activity and potentially better pharmacological properties are presented.
Graphical abstractA series of pyridopyrimidine derivatives were synthesized and evaluated for their ability to inhibit cyclic nucleotide synthesis in the presence of stable toxin a of Escherichia coli.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eric A. Tanifum, Alexander Y. Kots, Byung-Kwon Choi, Ferid Murad, Scott R. Gilbertson,