| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373757 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We report identification of 2-cyclohexylcarbonylbenzimidazole 7c as potent, orally available and brain-penetrable ORL1 antagonist. Compound 7c showed satisfactory pharmacokinetic profiles and brain penetrability in laboratory animals, and good in vivo antagonism.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kensuke Kobayashi, Minaho Uchiyama, Hirobumi Takahashi, Hiroshi Kawamoto, Satoru Ito, Takashi Yoshizumi, Hiroshi Nakashima, Tetsuya Kato, Atsushi Shimizu, Izumi Yamamoto, Masanori Asai, Hiroshi Miyazoe, Akio Ohno, Mioko Hirayama, Satoshi Ozaki,