| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373765 | Bioorganic & Medicinal Chemistry Letters | 2009 | 8 Pages |
Abstract
Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 < 10 μM).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuefen Zhou, Khang Vu, Yongsheng Chen, John Pham, Thomas Brady, Gang Liu, Jinhua Chen, Joonwoo Nam, P.S. Murali Mohan Reddy, Qingyan Au, Il Sang Yoon, Marie-Helene Tremblay, Gary Yip, Charmian Cher, Bin Zhang, Jack R. Barber, Shi Chung Ng,