Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373801 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Reaction of 17α-bromo-21-iodo-3β-acetoxypregn-5-en-20-one with ammonia, primary, and secondary amines is simple and convenient method for preparation of [17(20)E]- and [17(20)Z]-pregna-5,17(20)-dien-21-oylamides. Synthesis and characteristics of 12 related amides are presented. Primary testing on cells proliferation indicated differing effects of synthesized compounds on androgen insensitive MCF-7 cells and androgen sensitive LNCaP cells.
Keywords
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Chemistry
Organic Chemistry
Authors
Sergey V. Stulov, Maria G. Zavialova, Arif R. Mehtiev, Roman A. Novikov, Yaroslav V. Tkachev, Vladimir P. Timofeev, Alexander Yu Misharin,