| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373812 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
Graphical abstractCompound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul E. Harrington, David J. St. Jean Jr., Jeffrey Clarine, Thomas S. Coulter, Michael Croghan, Adam Davenport, James Davis, Chiara Ghiron, Jonathan Hutchinson, Michael G. Kelly, Fred Lott, Jenny Ying-Lin Lu, David Martin, Sean Morony, Steve F. Poon,