| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373813 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Biphenylketones were identified as novel inhibitors of NFκB activation. Structure–activity studies led to the identification of compound 4c, which had good potency against osteoclasts (IC50 = 0.8 μM), showed oral activity, and was able to completely prevent inflammation and bone loss in vivo.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Iain R. Greig, Emmanuel Coste, Stuart H. Ralston, Rob J. van’t Hof,