Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach

We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.

Graphical abstractA novel NR2B-selective NMDAR antagonist, LSP10-0500, was identified using a ligand-based virtual screening approach.Figure optionsDownload full-size imageDownload as PowerPoint slide