| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373835 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The first successful Pd/C-mediated Sonogashira coupling of iodothiophene with terminal alkynes in water is described here. Pd/C-CuI-PPh3 was found to be an efficient catalyst system for this coupling reaction. Using this economic and reliable process a variety of acetylenic thiophenes with a wide range of functional groups were prepared in good yields. Synthetic applications and in vitro anticancer properties of some of the compounds synthesized are described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sirisilla Raju, P. Rajender Kumar, K. Mukkanti, Pazhanimuthu Annamalai, Manojit Pal,