| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373843 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV Ki = 2 nM) and exhibits excellent selectivity and no species specificity against rat and human enzymes. The X-ray structure confirms that the binding mode of 7 to rat DPPIV is similar to the parent xanthines.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravi Kurukulasuriya, Jeffrey J. Rohde, Bruce G. Szczepankiewicz, Fatima Basha, Chunqui Lai, Hwan-Soo Jae, Martin Winn, Kent D. Stewart, Kenton L. Longenecker, Thomas W. Lubben, Stephen J. Ballaron, Hing L. Sham, Thomas W. von Geldern,