| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373851 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30 μM). For structure–activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 μM, 76.8%—HeLa and 46.3%—MCF7). The effect of the natural phytoalexin brassinin was also determined.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Péter Csomós, István Zupkó, Borbála Réthy, Lajos Fodor, George Falkay, Gábor Bernáth,