| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373860 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A new class of benzimidazolone p38 MAP kinase inhibitors was discovered through high-throughput screening. X-ray crystallographic data of the lead molecule with p38 were used to design analogues with improved binding affinity and potency in a cell assay of LPS-induced TNFα production. Herein, we report the SAR of this new class of p38 inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Abdelhakim Hammach, Antonio Barbosa, Faith Corbo Gaenzler, Tazmeen Fadra, Daniel Goldberg, Ming-Hong Hao, Rachel R. Kroe, Pingrong Liu, Kevin C. Qian, Mark Ralph, Christopher Sarko, Fariba Soleymanzadeh, Neil Moss,