| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373862 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.
Graphical abstractPPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate (AMC) template.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alan M. Warshawsky, Charles A. Alt, Joseph T. Brozinick, Allen R. Harkness, Eric D. Hawkins, James R. Henry, Donald P. Matthews, Anne R. Miller, Elizabeth A. Misener, Chahrzad Montrose-Rafizadeh, Gary A. Rhodes, Quanrong Shen, Jennifer A. Vance,