| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373867 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Synthesis and activity of derivatives at the O5 or O6 positions of 1-N-((S)-4-amino-2-hydroxybutyryl)-3′,4′-dideoxyneamine, which is the neamine moiety of arbekacin, were reported. Among these results, the 5-O-aminoethylaminocarbonyl derivative showed effective activity against Staphylococcus aureus expressing a bifunctional aminoglycoside-modifying enzyme AAC(6′)-APH(2″).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobuto Minowa, Yoshihisa Akiyama, Yukiko Hiraiwa, Kazunori Maebashi, Takayuki Usui, Daishiro Ikeda,