| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373882 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure–activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.
Graphical abstractA new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure–activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase](/preview/png/1373882.png "First Page Preview: Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase")
Authors
James Kempson, Junqing Guo, Jagabandhu Das, Robert V. Moquin, Steven H. Spergel, Scott H. Watterson, Charles M. Langevine, Alaric J. Dyckman, Mark Pattoli, James R. Burke, XiaoXia Yang, Kathleen M. Gillooly, Kim W. McIntyre, Laishun Chen, John H. Dodd,