Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373889 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A water-soluble calixarene-based heterocyclic podand incorporating a quinolone antibiotic subunit, the nalidixic acid, was synthesised and fully characterised. Its prodrug behaviour was assessed in vitro by HPLC, demonstrating the release of the tethered quinolone in model biological conditions. Microbiological studies performed on various Gram-positive and Gram-negative reference strains showed very interesting antibacterial activities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hugues Massimba Dibama, Igor Clarot, Stéphane Fontanay, Adel Ben Salem, Maxime Mourer, Chantal Finance, Raphaël E. Duval, Jean-Bernard Regnouf-de-Vains,