| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373899 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A novel class of 3,6-disubstituted 2-pyridinecarboxamide derivatives was designed based on X-ray analysis of the 2-aminobenzamide lead class. Subsequent chemical modification led to the discovery of potent GK activators which eliminate potential toxicity concerns associated with an aniline group of the lead structure. Compound 7 demonstrated glucose lowering effect in a rat OGTT model.
Graphical abstractA novel class of 3,6-disubstituted 2-pyridinecarboxamide derivatives was designed based on X-ray analysis of the 2-aminobenzamide lead class.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Morihiro Mitsuya, Kenji Kamata, Makoto Bamba, Hitomi Watanabe, Yasuhiro Sasaki, Kaori Sasaki, Sumika Ohyama, Hideka Hosaka, Yasufumi Nagata, Jun-ichi Eiki, Teruyuki Nishimura,