| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373900 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds.
Graphical abstractA series of trifluoromethyl, benzothiazolyl and thiazolyl ketone-containing peptidic compounds were synthesized and evaluated in vitro against SARS-CoV 3CLpro.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Thomas Regnier, Diganta Sarma, Koushi Hidaka, Usman Bacha, Ernesto Freire, Yoshio Hayashi, Yoshiaki Kiso,