| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373902 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Graphical abstractA series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Charles Francavilla, Eddy Low, Satheesh Nair, Bum Kim, Timothy P. Shiau, Dmitri Debabov, Chris Celeri, Nichole Alvarez, Ashley Houchin, Ping Xu, Ron Najafi, Rakesh Jain,