| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373914 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.
Graphical abstractThe SAR and X-ray crystal structure of a series of 4-azaindole inhibitors of c-Met kinase is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John Porter, Simon Lumb, Richard J. Franklin, Jose M. Gascon-Simorte, Mark Calmiano, Kelly Le Riche, Bénédicte Lallemand, Jean Keyaerts, Helen Edwards, Alison Maloney, Jean Delgado, Lloyd King, Anne Foley, Fabien Lecomte, James Reuberson,