| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373915 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A novel class of timolol derivatives with nitric oxide (NO)-donating moieties achieved chemical stability yet under physiologically relevant conditions released timolol and NO. Hindered esters A were designed and synthesized, whose ‘triggered’ release relied on enzymatic hydrolysis of the nitrate ester in A to B, that in turn cyclized to liberate timolol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Valerio Chiroli, Minerva R. Batugo, Stefano Biondi, Annalisa Bonfanti, Stefania Brambilla, David C. Gale, Lin Li, Daniela Miglietta, Fabio Nicoli, Ganesh A. Prasanna, Daniela Ronchetti, William F. Vernier, Wesley K.M. Chong,