| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373927 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
We have developed and characterized [35S]4a as a potent and selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R). Compound [35S]4a showed appreciable specific signals in brain slices prepared from wild-type mice but not from MCH1R deficient mice, confirming the specificity and utility of [35S]4a as a selective MCH1R radioligand for ex vivo receptor occupancy assays.
Graphical abstract[35S]4a was developed and characterized as a potent and selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masahiko Ito, Toshihiro Sakamoto, Takao Suzuki, Shinichiro Egashira, Minoru Moriya, Akane Ishihara, Hisashi Iwaasa, Hiroko Matsushita, Kazuho Nakase, Michael A. Wallace, Dennis Dean, Nagaaki Sato, Shigeru Tokita, Akio Kanatani,