| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373930 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted histone lysine methylating activity in cellular assays.
Graphical abstractN-Oxalylglycine (NOG) derivatives were synthesized and their inhibitory effect on histone lysine demethylase activity was evaluated. This study showed that NOG and compound 1 inhibit histone lysine demethylases both in enzyme assays and cellular assays.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shohei Hamada, Tae-Dong Kim, Takayoshi Suzuki, Yukihiro Itoh, Hiroki Tsumoto, Hidehiko Nakagawa, Ralf Janknecht, Naoki Miyata,