| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373931 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Antibiotic and hemolytic activities of gratisin (GR), cyclo(-Val1-Orn2-Leu3-d-Phe4-Pro5-d-Tyr6-)2, and fifteen GR analogues, which have various d-amino acid residues in place of d-Tyr6,6â² residues, were examined. Among them, [d-Orn6,6â²]-GR, [d-Lys6,6â²]-GR and [d-Arg6,6â²]-GR showed the strong activity against both Gram-positive and Gram-negative bacteria. In addition, the antibiotics showed significantly reduced toxicity against human blood cells compared with gramicidin S, cyclo(-Val1-Orn2-Leu3-d-Phe4-Pro5-)2.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Makoto Tamaki, Manabu Kokuno, Ichiro Sasaki, Yumiko Suzuki, Michiko Iwama, Kenichi Saegusa, Yusuke kikuchi, Mitsuno Shindo, Masahiro Kimura, Yoshiki Uchida,