DNA-interaction and in vitro antimicrobial studies of some mixed-ligand complexes of cobalt(II) with fluoroquinolone antibacterial agent ciprofloxacin and some neutral bidentate ligands

Six new mixed-ligand complexes of Co(II) with ciprofloxacin (Cip) and neutral bidentate ligands have been synthesized and characterized. Binding and cleavage of DNA with the complex were investigated using spectroscopic method, viscosity measurements and gel electrophoresis techniques. Antibacterial activity has been assayed against two Gram(−ve) and three Gram(+ve) microorganisms using the doubling dilution technique.

Graphical abstractSynthesized complexes were proved to be more potent bactericides than the ligands. Electrophoresis studies reveal that binding to DNA through classical intercalation mode prevent the organisms from reproducing.Figure optionsDownload full-size imageDownload as PowerPoint slide