| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374019 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b–d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC50 values 0.03 and 0.09 μM, against PaCa-2 cell line, respectively.
Graphical abstractA series of indolyl chalcones were synthesized and evaluated for their in vitro anti-proliferative activities against various cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dalip Kumar, N. Maruthi Kumar, Kanako Akamatsu, Eriko Kusaka, Hiroshi Harada, Takeo Ito,