| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374023 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A novel pyrrole-2-carboxamide series of p38α inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthesis program enabled rapid assessment of the series’ suitability for further lead optimisation studies.
Graphical abstractA novel pyrrole-2-carboxamide series of p38α inhibitors, discovered through the application of virtual screening, is presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenneth Down, Paul Bamborough, Catherine Alder, Amanda Campbell, John A. Christopher, Maria Gerelle, Steve Ludbrook, Dave Mallett, Geoff Mellor, David D. Miller, Rosannah Pearson, Keith Ray, Yemisi Solanke, Don Somers,