| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374029 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of sulfonamide CCR2 antagonists was identified by high-throughput screening. Management of molecular weight and physical properties, in particular moderation of lipophilicity and study of pKa, yielded highly potent CCR2 antagonists exhibiting good pharmacokinetic properties and improved potency in the presence of human plasma.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Simon Peace, Joanne Philp, Carl Brooks, Val Piercy, Kitty Moores, Chris Smethurst, Steve Watson, Simon Gaines, Mara Zippoli, Claudette Mookherjee, Robert Ife,