| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374051 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC50 values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nicolas Drogat, Robert Granet, Caroline Le Morvan, Gaëlle Bégaud-Grimaud, Pierre Krausz, Vincent Sol,