Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374054 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We describe an efficient and scalable procedure for the chemical synthesis of nucleoside 5′-phosphosulfates (NPS) from nucleoside 5′-phosphorimidazolides and sulfate bis(tributylammonium) salt. Using this method we obtained various NPS with yields ranging from 70–90%, including adenosine 5′-phosphosulfate (APS) and 2′,3′-cyclic precursor of 3′-phosphoadenosine 5′-phosphosulfate (PAPS), which are the key intermediates in the assimilation and metabolism of sulfur in all living organisms.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joanna Kowalska, Agnieszka Osowniak, Joanna Zuberek, Jacek Jemielity,