| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374056 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic properties.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Ana Escribano, Ana I. Mateo, Eva M. Martin de la Nava, Daniel R. Mayhugh, Sandra L. Cockerham, Thomas P. Beyer, Robert J. Schmidt, Guoqing Cao, Youyan Zhang, Timothy M. Jones, Anthony G. Borel, Stephanie A. Sweetana, Ellen A. Cannady, Nathan B. Mantlo,