| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374058 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The generation of novel CRTH2 ligands in heavily congested chemical space, by de novo design of libraries is disclosed. Novel (1719) compounds across seven libraries were synthesised. More than 100 of these compounds showed binding potency <3 μM against CRTH2, with the most potent being 247 nM. These libraries produced novel series and demonstrated that this approach is a viable one.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M. Abid Masood, Mark Gardner, Kevin Dack, David Winpenny, Graham Lunn,